Gene information
Official symbol NLRP3
Official full name NLR family pyrin domain containing 3
Gene type protein-coding gene
Chromosome1q44
Alias symbolAGTAVPRL; AII; AVP; FCAS; FCU; NALP3; PYPAF1; MWS; CLR1.1
Previous symbolC1orf7; CIAS1; DFNA34
Gene familyNLR family; Pyrin domain containing
Resources
Entrez Gene 114548
HGNC HGNC:16400
Ensembl ENSG00000162711
Vega OTTHUMG00000040647
UCSC uc001icr.4
GO terms: 72 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002828 regulation of type 2 immune response GO Biological Processes -8.52846045 8 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0009595 detection of biotic stimulus GO Biological Processes -6.46280795 7 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032088 negative regulation of NF-kappaB transcription factor activity GO Biological Processes -5.01152693 15 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032691 negative regulation of interleukin-1 beta production GO Biological Processes -9.98402343 15 More
GO:0032692 negative regulation of interleukin-1 production GO Biological Processes -11.9554195 18 More
GO:0042834 peptidoglycan binding GO Molecular Functions -3.15220350 5 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.90313372 12 More
GO:0043433 negative regulation of DNA-binding transcription factor activity GO Biological Processes -10.6964949 32 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045622 regulation of T-helper cell differentiation GO Biological Processes -5.35296451 10 More
GO:0046634 regulation of alpha-beta T cell activation GO Biological Processes -7.20313216 11 More
GO:0046635 positive regulation of alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051606 detection of stimulus GO Biological Processes -2.56190637 17 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0098586 cellular response to virus GO Biological Processes -6.52248641 17 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
Drug-Gene interaction
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Related drugs: 9 records
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
NM_004895.5:c.14229A>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
NM_004895.5:c.14240C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
NM_004895.5:c.14261A>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
NM_004895.5:c.14347A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
NACHT, LRR and PYD domains-containing protein 3 proteomics good predictor acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
NM_004895.5:c.2113C>A genomics myocardial infarction[diagnosis] myocardial infarction Varghese GP et al. Biomed Rep. 2013
NM_004895.5:c.2113C>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Jalil HM et al. Pak J Biol Sci. 2020
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